Parthenolide

It is a potential anticancer drug. It destroys acute myelogenous leukemia (AML) cells by inducing apoptosis, leaving normal bone marrow cells relatively unscathed. Moreover, the compound may get at the root of the disease because it also kills stem cells that give rise to AML.Parthenolide is under consideration as a potential cancer drug in combination with sulindac. Parthenolide is active against a parasite Leishmania amazonensis. Microtubule-interfering activity of parthenolide. Anti-inflammatory and anti-hyperalgesic effects of sesquiterpene lactones. Parthenolide blocks lipopolysaccharide-induced osteolysis through the suppression of NF-κB activity.